Two centuries ago, an English surgeon began noticing three elderly strangers with disrupted movements in the crowded streets of London. They shared similar characteristics of trembling hands, speaking difficulty, and postural instability. These symptoms were documented in ‘An Essay of the Shaking Palsy’ by the surgeon James Parkinson. While the discovery of the disease was merely through observation, there has been tremendous progress in the science of shaking palsy, later renamed as Parkinson’s disease in regards to the surgeon’s name. In a paper published this month by the Journal of Young Investigators, Diego Machado Reyes and Dr. Ana Lilia Reyes-Herrera explore the many ways technology has advanced the diagnosis and monitoring of people with Parkinson’s.
Streamlining Clinical Trials to Make Them Work for Everyone: A Conversation with Dr. Heidi Gardner
As the world is still combating the COVID-19 pandemic through mass inoculations and finding the definitive treatment, studying medicine efficacy and safety in the human biological system has never been more important. Before any treatment is approved, clinical trials are done to ensure that the new intervention works for every member of society. This, however, is not often the case as there are still many external obstacles to equitable clinical trials.
Press Release: Using Molecular Sponges, Not for Your Dishes!
If you look at each of the cells in our body, you will notice that cells, such as a neural cell and a red blood cell look completely different. Cells with different functions such as muscle cells, liver cells, heart cells, etc. all have differing looks; yet, these differences are not a variation in genes. All of the cells in an individual’s body have the same genetic information, and the dissimilarity that we observe are the result of regulating gene expression. Gene expression is the production of proteins, and in a cell not every part of the genome is used to make all the possible proteins. Rather, complex interactions between various molecules regulate our genes. Regulation of genes is important for both development and maintenance of one’s health. Disease states are linked to a dysregulation of genes, where some genes may be overexpressed or expressed when it should be silent. Therefore, scientists have been looking into gene regulation to distinguish the root causes of certain diseases and innovate therapeutic agents.
A Review of the Implementation of Computer-Based Systems to Detect and Monitor Parkinson’s Disease
Parkinson’s disease is the second most common neurodegenerative disorder, affecting nearly 1 million people in the US and is predicted to keep increasing. Parkinson’s disease is difficult to diagnose due to the similarity with other diseases that share the parkinsonian symptoms, thus increasing the probabilities of misdiagnosis. Therefore, it is relevant to develop diagnostic tools that are quantitatively based and monitoring tools that will improve the patient’s quality of life. Computer-based assessment systems have shown to be successful in this field through diverse approaches that can be classified in two main categories: sensor-based and computer vision-based systems. In this article a comprehensive review is performed to analyze the different approaches taken; moreover, their challenges and future perspectives are discussed.
Negative Emissions Technologies: A Decisive Step Towards a Better Tomorrow
On April 22nd 2016, one hundred seventy-four states and the European Union signed the Paris Agreement; an international framework that aims to avert an irreversible climate catastrophe. Aware of the disastrous consequences climate change has on our planet these nations compromise, inter alia, to keep global warming at least under 2ºC, with an ideal target of 1.5ºC.
Since April 2016, many efforts have been made to restrain the causes of global warming yet climate scientists warn the 1.5ºC target will not be met unless global carbon emissions reach net-zero around mid-century. Luckily, mechanisms exist to achieve “net-zero”: Negative Emission Technologies.
Altering Communities: From Microbes to Biological Machines
What makes us human: our genes or the microbes that colonize us? Throughout our body the microbes that constitute our microbiome outnumber our human cells, meaning there are more microbes present on us than our own genetically distinct cells (Gallager). Moreover, our microbiome contains more genetic information than our human genome (University of Washington). Does this evidence of a large amount of life colonizing our bodies influence our lives? Indeed, the microbiome has been linked to health outcomes such as the development of autoimmune diseases and contraction of non-communicable diseases (West et al.).
New Target Associate Specific Drug Levels Within Race Against Cancer
A Primer on Linear Algebra in Machine Learning
With the advent of many new machine learning packages and tools being open-sourced, there has been increased popularity in machine learning applications among various industries. From predicting the best routes for pharmaceutical drug delivery to gaining insights on stock movements using prior financial data, machine learning has been ever-expanding for the past few decades. Although there has been an increase in its utilization, there are still many who do not know the underlying math used in these algorithms.
Let’s Get This Bread: Sourdough May Reduce Immune Response
In recent years, researchers have examined links between diet and health outcomes, especially as they pertain to gut microbiota. Several of these studies focus on sourdough due to its unique fermentation process. A recent study found that wheat bread made with sourdough may reduce immunoreactivity and certain metabolic enzyme activity with consumption.
Artificial Intelligence, Machine Learning, and Deep Learning: Are They All the Same?
Artificial Intelligence (AI) is a field of computer science and computer systems that emphasizes frameworks to perform tasks that conventionally are perceived as requiring human cognition and intelligence. It is an industry that has been progressing and integrating into our daily lives through the technologies we use. With recent scientific developments, Machine Learning (ML) and Deep Learning (DL) have been prominent names associated with AI. While there is an overlap among all of them, they are not the same.
Press Release: RNA Strand Variations Dictate Plant’s Behavior to Greet the Changing Season
The bursting of green buds into a vivid splash of white petals to mark the arrival of spring is a feast for the senses. A fully visible spectacle to human sight, there is more to the plant’s biological phenomena than what meets the eye. Deep in a structure of Arabidopsis halleri’s leaves, a molecular machinery governs the entire behavior of this perennial weed. An exhaustive genetic modulation corresponding to seasonal pattern exists as corroborated in a study by Daniel Phillips, Dr Wenbin Guo, and Dr Runxuan Zhang recently published in the Journal of Young Investigators (Phillips, Guo, Zhang, 2021).