Epigenetics Misregulation and Obesity or Epigenetics: Another Important Piece in the Obesity Puzzle

Epigenetics Misregulation and Obesity or Epigenetics: Another Important Piece in the Obesity Puzzle

In 2016, the World Health Organization (WHO) estimated that 1.9 billion individuals over the age of 18 are overweight which comprises roughly one-third of the world population. Obesity is defined by the presence of abnormal or excessive fat which presents excessive risks to an individual’s health. Consequently, obesity is a risk factor for diseases such as cardiovascular disease, diabetes, and cancer. Health care professionals and world organization bodies, such as the WHO, highlight that obesity is preventable. As such, there has been significant research conducted to understand the causes of the pandemic.

Press Release: The Role of DNA Mismatch Repair Genes in Chemotherapy Resistance

Press Release: The Role of DNA Mismatch Repair Genes in Chemotherapy Resistance

In their recently published research paper, Kulsom Nuuri and Dr. Yoana Arroyo-Berdugo from the University of Roehampton presented their investigation of the origin of chemotherapy resistance in pediatric patients suffering from acute lymphoblastic leukemia (ALL). In ALL, large numbers of lymphoblasts develop from stem cells in the bone marrow and quickly crowd out other blood cells that are important for fighting infection, transporting oxygen, and clotting. Eventually, these cancerous cells spread to the blood and other organs. Without treatment, ALL can be fatal within just a few months.

Analysis of expression of MSH2 and MSH3 genes in Mixed Lineage Leukemia (MLL)-Acute Lymphoblastic Leukemia (ALL) human cell lines

Analysis of expression of MSH2 and MSH3 genes in Mixed Lineage Leukemia (MLL)-Acute Lymphoblastic Leukemia (ALL) human cell lines

Around 803 new cases of Acute Lymphoblastic Leukemia (ALL) are diagnosed in the United Kingdom every year (Cancer Research UK, 2018). Cytarabine (Ara-C) is a chemotherapeutic drug used to treat leukemic patients, however, chemotherapy resistance occurs frequently. Mechanisms of chemotherapy resistance to Ara-C are poorly understood. DNA mismatch repair (MMR) pathway is one of the pathways responsible to repair errors caused during DNA replication. MMR can also repair damage due to Ara-C and therefore a proficient MMR can confer resistance to Ara-C. Our project aims to investigate the expression of MMR genes MSH2 and MSH3 in ALL carrying Mixed Lineage Leukemia (MLL), also known as KMT2A, chromosomal translocations.