Magic mushroom users often describe a feeling of having their minds expanded, but a new study reveals that this psychedelic state results from diminished brain activity. A recently published study interpreting functional brain scans of volunteers under the influence of the active psychedelic compound in magic mushrooms, psilocybin, has provided scientists with a new view of how the psychedelic state is achieved in the brain—one that may elucidate how to treat depression and headaches.